NCT06399666

Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation

Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation - IERV Trial

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 182 (estimated)
• Sponsor: Vrinnevi Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV. Previous studies have primarily focused on high-sensitivity CRP (hsCRP), CRP, and IL-6, while other inflammatory indexes and gene scores might hold greater value. This prospective cohort study is planning to include 182 patients with persistent atrial fibrillation, planned for electrical cardioversion, and \>18 years at two medium-sized hospitals in Sweden. Blood samples will be collected prior to electrical cardioversion and at 7-, 30-, 90-, and 180-days follow-up. Atrial fibrillation recurrence will be evaluated at follow-up or upon patient request and diagnosed with 12-lead ECG. An interim analysis will be conducted after more than 80 patients have been included. If the results from univariate and/or multivariable logistic regression on inflammatory markers and genetic expression regarding atrial fibrillation recurrence are significant, the study will be concluded.

Conditions

• Atrial Fibrillation
• Inflammation
• Genetic Predisposition to Disease

Interventions

Type	Name	Description
OTHER	Blood sampling	Blood sampling

Timeline

• Start date: 2023-10-30
• Primary completion: 2025-06-01
• Completion: 2026-02-28
• First posted: 2024-05-06
• Last updated: 2024-09-19

Locations

2 sites across 1 country: Sweden