NCT06398821

G3P-01 in Volunteers With Elevated Galectin-3

A Dose Ranging Target Engagement Study of a Food-Grade Pectic Food Supplement (G3P-01) in Volunteers With Elevated Levels of Galectin-3 - the Galaxy Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: General Practitioners Research Institute · Network
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Accepted

Summary

G3P-01 is an investigational pectin extracted, enriched and purified from commercial squash puree intended for human consumption. Pectins are an important constituent of fruits and vegetables, and health benefits are attributed to its intake. Some of the health benefits of pectins are attributed to inhibition of galectin-3. This study investigates if 30-days of G3P-01 intake in individuals with elevated galectin-3 induces biomarker changes that can be attributed to target engagement. Participants will be randomized into four groups (placebo, 100mg, 250mg and 1000mg G3P-01).

Conditions

• Galectin 3
• Healthy Aging

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	G3P-01	Nutritional supplement to promote healthy aging
DIETARY_SUPPLEMENT	Placebo	Placebo

Timeline

• Start date: 2023-10-18
• Primary completion: 2024-04-16
• Completion: 2024-05-30
• First posted: 2024-05-03
• Last updated: 2024-08-09

Locations

1 site across 1 country: Netherlands