NCT06397430

Nutritional Support for Patients Operated for Malignant Tumors in HPD Zone

Nutritional Support for Patients Operated on for Malignant Tumors of the Hepatico-pancreato-duodenal (HPD) Zone in the Early Postoperative Period

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 91 (actual)
• Sponsor: Karaganda Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

A comprehensive comparative analysis of the effectiveness of isolated enteral, isolated parenteral and mixed type of nutritional support in the early postoperative period in patients after operations performed on the malignant neoplasms of hepatico-pancreatico-duodenal zone.

Detailed description

A prospective, longitudinal, parallel study and retrospective analysis of the results of treatment of 91 patients with malignant tumors of the hepatico-pancreato-duodenal zone who underwent the following operations: 1. resection of various segments of the liver; 2. hemihepatectomy; 3. transhepatic drainage of the right and left hepatic duct; 4. bypass gastroenteroanastomosis or cholecystenteroanastomosis with interintestinal enteroenteroanastomosis according to Brown; 5. gastro-pancreato-duodenal resection; 6. corpore-caudal resection of the pancreas with splenectomy. The first group (n=31) included patients who received enteral nutrition (EN) after surgery. The second group (n=30) included patients who received parenteral nutrition (PN) and the third group (n=30) who received mixed nutrition (MN), as a variation of the partial parenteral nutrition technique, in the early postoperative period. Some nutritional status indicators available for determination at the Oncology Clinic were assessed - body mass index (weight measurements were carried out before surgery, on the 5th, 10th and 15th days), basal metabolic rate (calculated using the Harris-Benedict equation, based on anthropometric data of the patient (gender, age, weight and height).), laboratory parameters: blood hemoglobin, lymphocytes, total protein, serum albumin, serum transferrin, total bilirubin and direct, alanine aminotransferase (ALT), aspartate aminotransferase (AST), which are related to the traditional method for assessing nutritional status

Conditions

• Nutritional Support
• Hepato-Biliary Neoplasm
• Postoperative

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	parenteral nutrition supplements	parenteral nutrition
DIETARY_SUPPLEMENT	enteral nutrition supplements	enteral nutrition
DIETARY_SUPPLEMENT	mixed nutrition supplements	mixed nutrition

Timeline

• Start date: 2017-12-01
• Primary completion: 2020-02-28
• Completion: 2020-02-28
• First posted: 2024-05-02
• Last updated: 2024-05-02

Locations

1 site across 1 country: Kazakhstan