NCT06392308

The Impact of Smoking on the Prognosis of Elderly Surgical Patients

The Impact of Smoking on Postoperative Delirium and Recovery Quality in Elderly Surgical Patients

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 121 (estimated)
• Sponsor: Affiliated Hospital of Nantong University · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: —

Summary

Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality. However, the underlying mechanisms of its onset are not yet fully understood. Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction, and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis. Yet, no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota. This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers.

Detailed description

After obtaining approval from the ethics committee, patients are recruited, informed of the trial process and potential risks, and their informed consent is obtained and signed. According to the WHO definition, patients are classified into smokers (defined as those who smoke more than one cigarette per day continuously or cumulatively for six months; more than four times a week but averaging less than one cigarette per day) and non-smokers (never smoked). Fecal and blood samples are collected from both groups of patients preoperatively, and perioperative data is gathered. Postoperatively, an uninformed observer assesses the patients for delirium and recovery quality.

Conditions

• Delirium, Postoperative

Interventions

Type	Name	Description
OTHER	none intervention	No interventions are administered to either group of patients.

Timeline

• Start date: 2025-09-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-04-30
• Last updated: 2025-01-16

Locations

1 site across 1 country: China