NCT06390202

Uterine Artery Diastolic Notching & Apelin-13 and 36

Investigation of the Relationship Between Uterine Artery Doppler Diastolic Notching and Serum Apelin-13 and Apelin-36 Concentrations Between the 11th and 14th Weeks of Pregnancy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 88 (actual)
• Sponsor: Umraniye Education and Research Hospital · Other Government
• Sex: Female
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.

Detailed description

Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration. Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy. We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.

Conditions

• Diagnosis

Interventions

Type	Name	Description
OTHER	no intervention	there is no intervention in this study

Timeline

• Start date: 2023-03-01
• Primary completion: 2023-10-30
• Completion: 2024-01-01
• First posted: 2024-04-30
• Last updated: 2024-04-30

Locations

1 site across 1 country: Turkey (Türkiye)