NCT06387940

Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels

Investigation Into the Postprandial Effects of Varying Calorie Content of Low-Carbohydrate Diets on Human Metabolic Health

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Surrey · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.

Detailed description

Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	nEB Diet, followed for 36 hours	nEB diet first, then LC25 and LCEB in random order with a 5 days washout between each diet
OTHER	LC25 Diet, followed for 36 hours	LC25 diet first, then nEB and LCEB in random order with a 5 days washout between each diet
OTHER	LCEB Diet, followed for 36 hours	LCEB diet first, then LC25 and nEB in random order with a 5 days washout between each diet

Timeline

• Start date: 2019-11-05
• Primary completion: 2020-04-01
• Completion: 2022-11-20
• First posted: 2024-04-29
• Last updated: 2024-04-29

Locations

1 site across 1 country: United Kingdom