NCT06387654

Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases

Constitution of a Collection of Biological Samples With the Aim of Carrying Out Clinico-biological and Physiopathological Investigations of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 6 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The aim of this project is to start a biological and clinical collection of patients presenting autoimmune, dysimmune or auto-inflammatory dermatological diseases. This collection will provide appropriate biological samples to identify new biomarkers and to be accessible to the medical, scientific and industrial communities for the identification of new therapeutic strategies.

Detailed description

Autoimmune diseases include around a hundred different clinical entities which are for the most part rare pathologies but which, in combination, concern 5-8% of the adult population with a strong female predominance (FAI²R: the disease chain rare autoimmune and auto-inflammatory drugs, fai2r.org). The common denominator of all these diseases is based on the breakdown of self-tolerance which is the origin of self-reactivity and whose physiopathological mechanisms are still not fully understood, which generates numerous cross-sectional or fundamental studies. In addition to this complexity, there are significant inter-individual variabilities which lead to the definition of subgroups of patients on the basis of the clinical-biological profile and / or the response to treatments. Consequently, and in view of the need to establish the diagnosis early and then to propose the best treatment in the perspective of an individualized medicine, the clinical, biological and genetic characteristics of these subgroups of patients must be explored in order to improve diagnostic and therapeutic capacities.

Conditions

• Autoimmune Bullous Dermatosis
• Dysimmune Dermatological Diseases
• Auto-inflammatory Dermatological Diseases
• Skin Diseases

Interventions

Type	Name	Description
BIOLOGICAL	Blood sampling	Blood will be taken in larger quantity
BIOLOGICAL	Remainders of samples taken as part of the treatment	blood, CSF, saliva, stools, urine, other biological fluids and tissue biopsies, hair follicles

Timeline

• Start date: 2024-05-06
• Primary completion: 2029-04-01
• Completion: 2034-04-01
• First posted: 2024-04-29
• Last updated: 2026-03-17

Locations

1 site across 1 country: France