NCT06386471

Personalized GI Motility Responses to Diet

Personalized Gastrointestinal Motility Responses to Dietary Fiber and Gut Microbial Metabolites

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: All
• Age: 21 Years – 63 Years
• Healthy volunteers: Accepted

Summary

The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3) circulating postprandial appearance of metabolites important to cardiometabolic health including glucose, triglycerides, and cholesterol. Participants will be asked to consume a Smartpill monitoring device that records metrics of gastrointestinal motility in response to whole or refined grains, monitor cardiometabolic metabolties over an 8 hour postprandial window, and provide a fecal sample for microbiome-related analyses.

Conditions

• Nutritional and Metabolic Diseases
• Gastrointestinal Dysfunction
• Cardiovascular Diseases
• Dysbiosis

Interventions

Type	Name	Description
OTHER	Whole grain rye bread	Single consumption of 4.3 oz of whole grain rye bread
OTHER	Refined grain rye bread	Single consumption of 4.3 oz of refined grain rye bread

Timeline

• Start date: 2024-03-07
• Primary completion: 2024-06-12
• Completion: 2025-06-02
• First posted: 2024-04-26
• Last updated: 2024-04-26

Locations

1 site across 1 country: United States