NCT06385912

Systematic Lymphadenectomy During Interval Debulking Surgery in Advanced Epithelial Ovarian Cancer

Systematic Lymphadenectomy During Interval Debulking Surgery in Advanced Epithelial Ovarian Cancer: a Multicenter Real-world Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,090 (actual)
• Sponsor: Tongji Hospital · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The study aims to investigate the prognostic and postoperative complication relevance of lymphadenectomy in advanced epithelial ovarian cancer patients who received neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The main question it aims to answer is: Does systematic lymphadenectomy during interval debulking surgery have a significant impact on survival in patients with advanced epithelial ovarian cancer who have received neoadjuvant chemotherapy? The progression-free survival (PFS), overall survival (OS), and postoperative complication were compared between the lymphadenectomy and no lymphadenectomy groups to answer the question.

Detailed description

The study aims to investigate the prognostic and postoperative complication relevance of lymphadenectomy in advanced epithelial ovarian cancer patients who received neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). The study included patients with histologically confirmed advanced epithelial ovarian cancer who received IDS at seven tertiary hospitals in China from 2006 to 2021. The progression-free survival (PFS), overall survival (OS), and postoperative complication were compared between the lymphadenectomy and no lymphadenectomy groups. Propensity score matching (PSM) and overlapping weight (OW) analyses were performed to minimize selection bias.

Conditions

• Ovarian Cancer
• Postoperative Complications
• Neoadjuvant Therapy
• Lymph Node Excision

Interventions

Type	Name	Description
PROCEDURE	lymphadenectomy	Systematic pelvic and para-aortic lymphadenectomy during IDS in lymphadenectomy group

Timeline

• Start date: 2006-07-01
• Primary completion: 2021-02-10
• Completion: 2021-02-10
• First posted: 2024-04-26
• Last updated: 2024-04-26

Locations

1 site across 1 country: China