NCT06384495

How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Combining cortical tDCS with behavioral interventions has been shown to have beneficial outcomes in individuals post-stroke. However, cerebellar tDCS is a fairly new approach for individuals with unilateral cortical stroke and there has not been reports of duration of effect of tDCS applied to the cerebellum in this population. Information gained from this study will serve to fill knowledge gaps on the duration of effect of cerebellar tDCS and the effects of polarity. The purpose of this study is to determine the duration of effect of ventro-lateral cerebellar transcranial direct current stimulation (tDCS) in healthy adults through cortical excitability (CE), cognitive, language and motor assessment measures. Primary aim: Compare baseline CE from left motor cortex of first dorsal interosseous (FDI) and orbicularis oris (OO) areas to CE post cerebellar tDCS at 15 minutes, 45 minutes and 75 minutes. Single-pulse and paired-pulse transcranial magnetic stimulation (TMS) will be used to measure and compare stimulus response curve (S/R curve), cortical silent period (CSP) and short-interval intracortical inhibition (SICI) in the hand area and facial area of the left primary motor cortex at each time point. Secondary aim: Compare baseline performance on cognition, motor learning and language tasks to performance at 15, 45 and 75 minutes after receiving tDCS. Digit Symbol Substitution Test (DSST), Serial Reaction Time Test (SRTT) and Lexical Decision tasks will be presented via a computer interface.

Conditions

• Stroke

Interventions

Type	Name	Description
PROCEDURE	REAL-A	one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
PROCEDURE	REAL-C	one session of 2mA for 20 minutes to the right ventro-lateral cerebellum
PROCEDURE	SHAM	one session of sham tDCS for 20 minutes to the right ventro-lateral cerebellum.

Timeline

• Start date: 2024-07-15
• Primary completion: 2025-08-10
• Completion: 2025-08-10
• First posted: 2024-04-25
• Last updated: 2025-08-24

Locations

1 site across 1 country: United States