NCT06383247

The Efficacy and Safety of Precision REpetitive Transcranial Magnetic Stimulation in Alleviating Motor Symptom in Parkinson's Disease

A Randomized, Double-blind, Multicenter, Placebo-controlled Trial (PRESS-PD)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 290 (estimated)
• Sponsor: Anhui Medical University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and widely used neuromodulation technology. Small sample studies have shown that rTMS treatment can significantly improve the symptoms of Parkinson's disease(PD) and delay the progression of the disease. In order to further explore the effectiveness of rTMS in the treatment of PD and lay the foundation for its clinical promotion, our research team plans to conduct a randomized double-blind controlled study of rTMS in the treatment of PD in multiple centers across the country.

Detailed description

This is a multi-center, double-blind, randomized controlled study that will be implemented in multiple hospital centers in China. In this study, the supplementary motor area (SMA) of the dominant hemisphere was selected as the stimulation target, and continuous theta burst stimulation (cTBS) sequence contact stimulation was used for a course of continuous stimulation for 7 days to observe the changes in clinical symptoms before and after the intervention.

Conditions

• Parkinson Disease
• Transcranial Magenetic Stimualtion
• Supplementary Motor Area

Interventions

Type	Name	Description
OTHER	transcranial magnetic stimulation	The stimulations were performed by MagStim Rapid2.

Timeline

• Start date: 2024-12-06
• Primary completion: 2026-12-31
• Completion: 2028-12-31
• First posted: 2024-04-25
• Last updated: 2025-06-17

Locations

1 site across 1 country: China