NCT06381245

First-time Ablation of Atrial Fibrillation Registry

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia affecting millions globally, with projections indicating a doubling of cases by 2050. AF is linked to heightened cardiovascular risks like stroke and increased healthcare costs. Ablation, targeting the arrhythmia substrate, is a method to manage AF, yet recurrence rates remain high (20-45% in the first year). Studies highlight the impact of comorbidities, AF characteristics, ablation techniques, and myocardial remodeling markers on AF progression and ablation efficacy. However, there's no definitive guidance on selecting these factors for predicting treatment success. The aim of this study is to investigate predictors of successful AF ablation in the following areas: (a) clinical factors, (b) electrophysiological, (c) electrocardiographic, (d) ultrasound, (e) cardiac anatomy, (f) biomarkers.

Detailed description

AF is a multifactorial disease influenced by many possible mechanisms. This study will examine several different predictors of successful AF ablation: (a) clinical factors, (b) electrophysiological, (c) electrocardiographic, (d) ultrasound, (e) cardiac anatomy, (f) biomarkers. Analysis of these factors will help determine the optimal combination of predictors of successful ablation. This combination of prognostic factors can then be used to tailor therapeutic decisions specifically to individual patients and to improve patient selection for invasive treatment. Better patient selection and choice of ablation type can help increase success rates and avoid unnecessary procedures and their associated risks.

Conditions

• Atrial Fibrillation
• Arrhythmia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	PPG-based remote heart rhythm/rate monitoring	PPG-based remote heart rhythm/rate monitoring
DIAGNOSTIC_TEST	ECG-based remote heart rhythm/rate monitoring	ECG-based remote heart rhythm/rate monitoring
DIAGNOSTIC_TEST	Transthoracic and transesophageal echocardiography examination	Transthoracic and transesophageal echocardiography examination
DIAGNOSTIC_TEST	Liver ultrasound examination	Liver ultrasound examination
DIAGNOSTIC_TEST	Rotational angiography with three-dimensional reconstruction	Rotational angiography with three-dimensional reconstruction
DIAGNOSTIC_TEST	Blood-derived biomarker analysis	Blood-derived biomarker analysis
DIAGNOSTIC_TEST	Mobile health-based spirometry	Mobile health-based spirometry

Timeline

• Start date: 2023-12-01
• Primary completion: 2026-03-31
• Completion: 2026-03-31
• First posted: 2024-04-24
• Last updated: 2024-08-13

Locations

1 site across 1 country: Poland