NCT06380140

Relationship Between Acute Phase Markers and Post-operative Pain in Open Tension-free Inguinal Hernia Repair: An Observational Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 71 (estimated)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Many patients undergoing inguinal hernia repair are prone to developing acute and chronic post-operative pain. The aim of the study is to show a possible correlation between pain and acute phase proteins in order to: * predict the severity of pain; * select most suitable pain relief therapy for the patient.

Detailed description

The day after surgery, some serum markers are determined by a blood sample. The markers analyzed are: * Leukocytes; * C-reactive protein (CRP); * D-dimer; * Fibrinogen; * Neutrophil-to-Lymphocyte Ratio (NLR). Pain level is assessed using the NRS scale at different times: * 1st post-operative day; * 7th post-operative day; * One month after surgery; * Three months after surgery; * Six months after surgery. Other data collected for the study are: gender, age, BMI.

Conditions

• Post Operative Pain
• Inguinal Hernia

Interventions

Type	Name	Description
PROCEDURE	Open Tension-free Inguinal Hernia Repair	A blood sample is taken the day after surgery

Timeline

• Start date: 2023-05-03
• Primary completion: 2024-03-03
• Completion: 2025-12-31
• First posted: 2024-04-23
• Last updated: 2024-04-23

Locations

1 site across 1 country: Italy