NCT06379568

Risk of Aspergillus Infection in Patients With Chronic Lung Disease

Risk of Aspergillus Infection in Patients With Chronic Structural Lung Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 209 (actual)
• Sponsor: Lin Chen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined.

Detailed description

Patients with chronic lung disease were identified as positive for Aspergillus fumigatus through sputum microscopy. According to diagnostic criteria, patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group, while the remaining patients were included in the Aspergillus colonization group. Then,Risk factors for aspergillus pneumonia, invasive pulmonary aspergillus disease, and chronic pulmonary aspergillus disease, such as the use of high-dose corticosteroids, inhaled corticosteroids, and the extent of damage to basic lung structures, were identified by comparing the aspergillus colonization group with the aspergillus infection group.

Conditions

• Fungal Infection Lungs

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2022-07-01
• Primary completion: 2024-01-31
• Completion: 2024-01-31
• First posted: 2024-04-23
• Last updated: 2024-04-23

Locations

1 site across 1 country: China