NCT06374433

Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (estimated)
• Sponsor: Università Vita-Salute San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Conditions

• Human Brain and Cognition

Interventions

Type	Name	Description
PROCEDURE	Occipital tACS at IAF-2Hz	tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)
PROCEDURE	Occipital tACS at IAF+2Hz	tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)
PROCEDURE	Frontal tACS at 4-7 Hz	tACS applied to frontal areas at 4-7 Hz
PROCEDURE	Occipital tRNS	tRNS applied to occipital brain regions
PROCEDURE	Frontal tRNS	tRNS applied to frontal brain regions
PROCEDURE	Sham/placebo tACS	tACS is activated only for 30 seconds and then turned off, thus resulting ineffective
PROCEDURE	Sham/placebo tRNS	tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective

Timeline

• Start date: 2024-06-13
• Primary completion: 2026-04-30
• Completion: 2026-12-31
• First posted: 2024-04-18
• Last updated: 2024-06-14

Locations

1 site across 1 country: Italy