NCT06365775

Multi-omics Characteristics and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

Multi-omics Characteristics and Prognosis in Patients With Idiopathic Sudden Sensorineural Hearing Loss

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Dan Bing · Academic / Other
• Sex: All
• Age: 4 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to describe the multi-omics characteristics and to learn about the prognostic factors in patients with idiopathic sudden sensorineural hearing loss (SSNHL). The main problems it aims to deal with are: * if there is a difference in data of exome and targeted sequencing among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls * if there is a difference in the parameter of MRI among patients with SSNHL affecting bilateral and unilateral sides, and healthy controls * to find out which factor from multi-omics data relates to outcomes of SSNHL * to develop the best prognostics model based on the multi-omics data. Participants will be received audiological tests, blood specimen collection and radiological examination. Researchers will explore the relationship between the multi-omics data and the prognosis and develop the predictive model.

Conditions

• Sudden Sensorineural Hearing Loss
• Hearing Loss, Sensorineural
• Hearing Loss, Sudden

Timeline

• Start date: 2024-04-23
• Primary completion: 2026-11-23
• Completion: 2026-11-23
• First posted: 2024-04-15
• Last updated: 2024-04-15