NCT06365411

GEnomic Medicine in Kidney Transplantation Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Western Sydney Local Health District · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation. 1. Determine non-HLA genomic mismatches between donor-recipient pairs which impact kidney allograft survival following transplantation 2. Derive polygenic risk scores on pre-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction 3. Derive polygenic risk scores on post-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction

Conditions

• Transplant Complication
• Kidney Transplant Rejection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biomarker discovery and validation - with focus on genomic biomarkers	Biomarker discovery and validation - with focus on genomic biomarkers

Timeline

• Start date: 2025-06-03
• Primary completion: 2030-01-01
• Completion: 2035-01-01
• First posted: 2024-04-15
• Last updated: 2025-03-28