NCT06362005

The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus

The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus (Randomized Clinical Trial)

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.

Detailed description

The signs and symptoms of the oral lichen planus lesion. 2-The associated oral symptoms. 3- Glutathione biomarker level as an antioxidant enzyme in saliva by ELISA analysis .

Conditions

• Lichen Planus, Oral

Interventions

Type	Name	Description
DRUG	Triamcinolone Acetonide 0.1% Oint	RCT
DRUG	Tacrollimus Topical	RCT
DRUG	Selenium	RCT
DRUG	Selenium & Triamcinolone Acetonide 0.1% Oint	RCT
DRUG	Selenium& Tacrollimus topical	RCT

Timeline

• Start date: 2024-05-01
• Primary completion: 2025-07-01
• Completion: 2025-10-01
• First posted: 2024-04-12
• Last updated: 2025-12-31

Locations

1 site across 1 country: Egypt