NCT06354712

Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

Clinical Study Evaluating the Efficacy and Safety of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of N-acetylcysteine in the prevention of radiotherapy induced oral mucositis in Head and Neck cancer patients.

Conditions

• Oral Mucositis (Ulcerative) Due to Radiation

Interventions

Type	Name	Description
DRUG	N-Acetyl-Cysteine with Institutional standard care	A potent antioxidant and anti-inflammatory drug (A precursor of the endogenous antioxidant glutathione)
DRUG	Institutional standard care	Benzydamine Mouthwash

Timeline

• Start date: 2024-04-04
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2024-04-09
• Last updated: 2025-01-15

Locations

1 site across 1 country: Egypt