NCT06354205

Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels

Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels in Infants Under 1 Year of Age Suspected of Systemic Bacterial Infection

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Ege University · Academic / Other
• Sex: All
• Age: 0 Years – 1 Year
• Healthy volunteers: Not accepted

Summary

Recently, it has been seen that investigations from saliva samples could be an alternative to those from blood samples. Saliva collection is a simple, non-invasive, cost-effective, and relatively easy method, making it potentially suitable as a new diagnostic tool in pediatric patients. In the current literature, elevated levels of saliva CRP, TNF-α, IL-6, and IFN-γ have been reported in inflammatory conditions. However, while there are animal studies suggesting the use of saliva PCT levels for focal diseases such as gingival inflammation and periodontitis and as a potential tool for non-invasive detection of sepsis, there is no human study regarding its use in systemic infections. The aim of this study is to evaluate the correlation between serum PCT levels and saliva PCT levels in children suspected of SBE and to determine the diagnostic value of saliva PCT.

Conditions

• Bacterial Infections
• Children, Only
• Procalcitonin
• Saliva

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Sliva Procalcitonin	Sliva Procalcitonin vs Blood procalcitonin

Timeline

• Start date: 2024-06-01
• Primary completion: 2025-03-01
• Completion: 2025-04-01
• First posted: 2024-04-09
• Last updated: 2024-04-09

Locations

1 site across 1 country: Turkey (Türkiye)