NCT06348212

Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Taipei Veterans General Hospital, Taiwan · Other Government
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to test whether the intervention of probiotics supplement can improve symptoms of long covid syndrome. Participants will be given probiotics or placebo capsules for two month. Symptom questionnaires, cognitive function, eeg and fecal sample are recorded/collected before and after the supplement. Researchers will compare the probiotic group and the placebo to see if probiotic supplement really make differences.

Detailed description

After the pandemic of covid-19, people found out that not only does it cause acute respiratory system symptoms, but it also affect many other systems even long after the acute symptoms have resolved, which is named the Long Covid Syndrome. Studies have shown that the gut microbiota of those suffering from long covid syndrome differ from that of healthy people and those who recovered from covid without getting long covid syndrome, which implied the possibility of probiotic supplement being an effective treatment to long covid. This double-blind parallel randomized control trail plans to supply participants with probiotics or placebo fortwo months. Symptom questionnaires, cognitive function, eeg and fecal sample will be recorded/collected before and after the supplement. Researchers will compare the two groups to see if they differ in the above measure and to see if the differences in symptoms and cognitive functions change correlate with gut microbiota change and fecal metabolite change.

Conditions

• Long COVID
• Brain Fog
• Cognitive Change

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus paracasei PS23	2 caps daily use
DIETARY_SUPPLEMENT	microcrystalline cellulose	2 caps daily use

Timeline

• Start date: 2024-04-01
• Primary completion: 2025-08-01
• Completion: 2025-12-01
• First posted: 2024-04-04
• Last updated: 2024-04-04