NCT06345638

Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD). * The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. * The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. * The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.

Conditions

• Sickle Cell Disease
• Vaso-occlusive Crisis

Timeline

• Start date: 2024-03-01
• Primary completion: 2025-06-17
• Completion: 2025-06-17
• First posted: 2024-04-03
• Last updated: 2025-08-05

Locations

3 sites across 1 country: United States