NCT06341829

Visuospatial and Affective Abilities in Parkinson Disease

Assessment and Rehabilitation of Visuospatial and Affective Abilities in Parkinson Disease

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 126 (estimated)
• Sponsor: IRCCS Centro Neurolesi Bonino Pulejo · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to investigate whether prismatic adaptation (PA) and virtual prismatic adaptation (VPA), a non-invasive neuromodulation technique, that involves the use of lenses that deviate the visual field, can modulate alexithyima and performance in visuospatial tasks in patients with Parkinson disease. Furthermore, brain activity during the prismatic adaptation and post-adaptation phases will be recorded using functional near-infrared spectroscopy (fNIRS) and high-density electroencephalography (HD-EEG). Based on these premises, the present project aims to investigate the deficits of the affective, motor and visuospatial abilities in Parkinson's patients and the modulation of disorders through prismatic adaptation (PA) and virtual prism adaptation (VPA). Finally, we would like to evaluate production of the tear film and correlate their quantity with the severity of PD as it could be proposed as a new, non-invasive biomarker.

Conditions

• Parkinson Disease
• Alexithymia
• Visuospatial/Perceptual Abilities

Interventions

Type	Name	Description
OTHER	Prismatic adaptation	Participants will fit with prismatic goggles that deviate their visual field by 13° either leftward or rightward. They will seat in front of a white horizontal board on which three target dots (5 mm diameter) were positioned at 0, -10 and +10° from their body midline at a distance of 57 cm from their eyes. They will perform a total of 150 verbally instructed pointing movements with their right index finger towards the right (+10°) and left (-10°) targets in a pseudorandom order.
DIAGNOSTIC_TEST	Schirmer test	Tear film will be collected from the right and left eyes.

Timeline

• Start date: 2024-04-30
• Primary completion: 2024-05-01
• Completion: 2026-02-28
• First posted: 2024-04-02
• Last updated: 2026-02-24

Locations

1 site across 1 country: Italy