NCT06338111

Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 67 (actual)
• Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and azurocidin 1 (AZU1) in 28-day mortality for patients with sepsis in Emergency Department.

Detailed description

The levels of the specified biomarkers were measured upon patient arrival at the Emergency Department (ED) and analyzed their correlation with 28-day mortality. The values of these biomarkers were monitored over the initial three days following admission to the ED, aiming to explore their potential in guiding the de-escalation of antibiotic treatment. Considering their prognostic significance, the main goal is to develop a novel scoring system tailored for use in the emergency department setting.

Conditions

• Sepsis Syndrome
• Emergency Department
• Biomarker

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ELISA Sepsis Biomarkers dosage	Observational

Timeline

• Start date: 2020-11-09
• Primary completion: 2022-12-06
• Completion: 2023-04-30
• First posted: 2024-03-29
• Last updated: 2024-06-07

Locations

1 site across 1 country: Romania