NCT06337227

Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3 (estimated)
• Sponsor: IRCCS SYNLAB SDN · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

Conditions

• Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	lncRNA signature analyses	Specific validation experiments will be performed by Real-Time PCR (C-reactive protein), Western Blot, flow cytometry and microscopy

Timeline

• Start date: 2023-10-19
• Primary completion: 2025-10-01
• Completion: 2026-10-01
• First posted: 2024-03-29
• Last updated: 2025-03-11

Locations

1 site across 1 country: Italy