NCT06335771

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity-Associated Diseases

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Bettina Mittendorfer · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss.

Conditions

• Obesity
• Nonalcoholic Fatty Liver
• Diabetes Type 2
• Healthy

Interventions

Type	Name	Description
OTHER	Dietary consultation weight loss intervention	Participants will meet with a member of the study team biweekly for about 6 months.

Timeline

• Start date: 2024-08-01
• Primary completion: 2028-03-01
• Completion: 2028-03-01
• First posted: 2024-03-28
• Last updated: 2025-07-18

Locations

1 site across 1 country: United States