NCT06334549

A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia

Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Dalian Municipal Central Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.

Detailed description

This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options \& specific mechanisms of the three vasopressors on rScO2 and CO.

Conditions

• Hypotension Drug-Induced

Interventions

Type	Name	Description
DRUG	Ephedrine-P	after induction of anesthesia, use total intravenous anesthesia maintained with propofol
DRUG	Phenylephrine-P	after induction of anesthesia, use total intravenous anesthesia maintained with propofol
DRUG	Norepinephrine-P	after induction of anesthesia, use total intravenous anesthesia maintained with propofol
DRUG	Ephedrine-S	after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
DRUG	Phenylephrine-S	after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
DRUG	Norepinephrine-S	after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane

Timeline

• Start date: 2024-03-05
• Primary completion: 2025-12-05
• Completion: 2025-12-05
• First posted: 2024-03-28
• Last updated: 2024-11-06

Locations

1 site across 1 country: China