Trials / Recruiting
RecruitingNCT06334172
The Role of Oxytocin in Regulating Blood Glucose
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- University Hospital, Gentofte, Copenhagen · Academic / Other
- Sex
- Male
- Age
- 20 Years – 50 Years
- Healthy volunteers
- Not accepted
Summary
Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.
Detailed description
Insulinotropic effects of oxytocin will be examined in 20 healthy men with body mass index (BMI) \< 27 kg/m2, during a graded glucose infusion test with concomitant intravenous infusion of synthetic oxytocin or placebo in a randomized, double-blinded design. This will determine the effect of oxytocin on glucose-stimulated insulin and glucagon secretion. Additional changes in plasma/serum concentrations of C-peptide, glucose, glucose-dependent insulinotropic polypeptid (GIP), glucagon-like peptide 1 (GLP-1), and lipids will be assessed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Oxytocin | Oxytocin |
| OTHER | Placebo | Saline |
Timeline
- Start date
- 2024-01-01
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
- First posted
- 2024-03-27
- Last updated
- 2024-04-04
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT06334172. Inclusion in this directory is not an endorsement.