NCT06331676

Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care

Developing a Complex ex Vivo Endometrial Tissue Model Based on Patient Biopsies to Assess and Optimise the Response to Current and Potential Treatments for Endometriosis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women. There is no cure for endometriosis. Hormonal treatments should be the first line therapy. The benefit-risk ratio of symptomatic treatment with hormone therapy varies greatly from one woman to another. The pathophysiology of endometriosis and the mechanisms of action of these treatments are still poorly understood. This may be due to the lack of an optimal experimental model for studying the disease. The aim of this project is to develop a complex ex vivo endometrial model recapitulating the organisation and properties of the human endometrium using innovative tissue bioengineering methods. This model will make it possible to develop a pre-clinical approach that predicts individual response to different types of hormonal treatment in order to optimise therapeutic choices and provide a better understanding of the effects of these treatments.

Conditions

• Endometriosis

Interventions

Type	Name	Description
PROCEDURE	Tissue collection	Eutopic and ectopic endometrium biopsies, additional blood and peritoneal fluid sampling
OTHER	Data collection	Questionnaire on menstrual health and history of hormone treatments for the research purpose

Timeline

• Start date: 2024-06-21
• Primary completion: 2028-03-21
• Completion: 2028-03-21
• First posted: 2024-03-26
• Last updated: 2026-01-30

Locations

2 sites across 1 country: France