NCT06329245

Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Children's Hospital of Fudan University · Academic / Other
• Sex: All
• Age: 0 Months – 18 Months
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants/toddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state.

Detailed description

The longitude observational study will be performed to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). We will follow up the subjects at 3-, 6-, 9-, 12-, 18-, 24-, 30-, and 36-month-old. Clinical diagnosis will be made on 24-month-old or after, with the DSM-5 as the diagnostic criterion.

Conditions

• Autism or Autistic Traits
• Healthy

Interventions

Type	Name	Description
OTHER	Do not take any interventions	Do not take any interventions

Timeline

• Start date: 2024-04-01
• Primary completion: 2029-01-01
• Completion: 2029-07-01
• First posted: 2024-03-25
• Last updated: 2026-03-16

Locations

1 site across 1 country: China