NCT06328621

Lung Cancer Risk Assessment and Etiology

Lung Cancer Risk Assessment &Amp; Etiology

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 109 (actual)
• Sponsor: City of Hope Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study examines the biological and social determinants that may increase the risk for lung cancer in patients and never-smoking individuals. Biological characteristics of a person can include their genetics and social determinants of a person can include their education, income, and environment, all of which can impact their health. Information collected in this study may help increase early detection of lung cancer.

Detailed description

PRIMARY OBJECTIVE: I. To assess the frequency of germline cancer susceptibility mutations in affected and unaffected individuals who have a personal or family history suggestive of high lung cancer risk. EXPLORATORY OBJECTIVES: I. To assess the frequency of abnormal radiographic findings in high-risk individuals unaffected with cancer who undergo low-dose computed tomography (CT) screening. II. Use patient survey and medical record data to explore the associations between social determinants of health, biological risk factors, family history and lung cancer incidence. III. To determine the sensitivity and specificity of liquid biopsy for detection of lung cancer in a never-smoking population. OUTLINE: Participants complete a survey over 40-45 minutes at baseline and undergo collection of blood samples at a scheduled clinical or research blood draw. Participants' medical records are also reviewed. Participants not diagnosed with lung cancer (i.e. "unaffected"), undergo a low-dose computerized tomography (CT) scan over 20 minutes.

Conditions

• Lung Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo collection of blood samples
PROCEDURE	Computed Tomography	Undergo low-dose CT
OTHER	Electronic Health Record Review	Review of medical records
OTHER	Survey Administration	Complete survey

Timeline

• Start date: 2021-07-02
• Primary completion: 2026-03-13
• Completion: 2026-03-13
• First posted: 2024-03-25
• Last updated: 2026-03-18

Locations

1 site across 1 country: United States