NCT06328270

Comparison of the Therapeutic Effects of Intra-Articular Injection of Ozone and Corticosteroid in Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Sisli Hamidiye Etfal Training and Research Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial aimed to involve patients aged 40-85 years who had been experiencing knee pain for at least 6 months and had received a clinical diagnosis of knee osteoarthritis through radiologic imaging. The patients were randomly assigned to two groups. One group received a 3-week intra-articular injection of 15 mg/ml ozone, while the second group received a 1 ml intra-articular injection of betamethasone. All patients were evaluated before treatment, as well as 4 and 12 weeks after the first dose of treatment. The study evaluated treatment efficacy using the Visual Pain Score (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	Ozone - oxygen Therapy	Ozone gas is a structurally unstable molecule that contains three oxygen atoms.
OTHER	Corticosteroid	1 ml betamethasone

Timeline

• Start date: 2020-09-01
• Primary completion: 2022-01-30
• Completion: 2022-03-30
• First posted: 2024-03-25
• Last updated: 2024-03-25

Locations

1 site across 1 country: Turkey (Türkiye)