NCT06324669

The Effect of a Ketone Drink on Blood Glucose Levels in People With Type 2 Diabetes

Investigating the Blood Glucose Lowering Effect of Exogenous Ketone Ingestion in People With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 41 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important in the treatment of type 2 diabetes (T2D). The purpose of this research is to determine if a ketone drink can lower blood sugar in people with T2D following a meal. This research will provide new knowledge about the regulation of blood sugar. This may also inform if ketone drinks could be used as a treatment for T2D.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone supplement	100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day
DIETARY_SUPPLEMENT	Placebo supplement	Placebo with stevia and bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day

Timeline

• Start date: 2024-03-16
• Primary completion: 2025-01-26
• Completion: 2025-01-26
• First posted: 2024-03-22
• Last updated: 2025-04-18

Locations

1 site across 1 country: United Kingdom