NCT06321627

Radiosensitivity of HPV-related Tumors: Towards a Genomic Approach

Radiosensitivity of HPV-related Tumors: Towards a Genomic Approach - ICARUS Project

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: European Institute of Oncology · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is therefore to analyze the genomic profiles of prognosis and radiosensitivity of Human Papilloma Virus (HPV) related tumors from different body sites (oropharynx, uterine cervix, and anus), considering them as a unified entity regardless of the site of origin within the body.

Detailed description

The present study (ICARUS - genomIC RAdiosensitivity viRUS) involves the collection of data (retrospective and prospective) from an extensive cohort of patients with HPV-related tumors of the oropharynx, cervix, and anus. The aim is to: 1. investigate the role of Cl2 in non-oropharyngeal HPV-related tumors, and 2. compare the Radiation Sensitivity Index (RSI) values of HPV-related tumors in patients who responded to radiotherapy (responders) with those of patients with radioresistant tumors (non-responders).

Conditions

• HPV-Related Carcinoma

Interventions

Type	Name	Description
RADIATION	Radiation therapy as curative treatment	Radiation therapy as curative treatment (exclusive, post-operative, with or without chemotherapy) for HPV-related squamous cell carcinomas of the oropharynx, uterine cervix, and anus

Timeline

• Start date: 2023-04-14
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2024-03-20
• Last updated: 2024-03-20

Locations

1 site across 1 country: Italy