NCT06316557

HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Zi-Xiao Li · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this clinical trial is to investigate the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in the cerebellum for individuals with post-stroke cognitive impairment. Participants will undergo rTMS in the cerebellar hemisphere opposite the lesion site, once daily for a total of five days.

Detailed description

The primary objective of this clinical trial is to investigate the effectiveness and safety of intermittent theta burst stimulation ( iTBS) in the cerebellum for individuals with post-stroke cognitive impairment. The trial aims to answer two main questions: (1) What is the effectiveness of iTBS in improving post-stroke cognitive impairment? (2) Is iTBS in the cerebellum safe for individuals with post-stroke cognitive impairment? Participants will undergo iTBS in the cerebellar opposite the lesion site, twice daily for five days. The control group will receive sham rTMS with the same parameters and positions.

Conditions

• Post-stroke Cognitive Impairment
• Ischemic Stroke

Interventions

Type	Name	Description
DEVICE	iTBS group	iTBS on the contralesional cerebellum, twice a day for seven days
DEVICE	control group	shame stimulation on the contralesional cerebellum, twice a day for seven days

Timeline

• Start date: 2025-01-01
• Primary completion: 2026-07-01
• Completion: 2027-04-01
• First posted: 2024-03-18
• Last updated: 2025-07-02

Locations

1 site across 1 country: China