NCT06313606

Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.

Conditions

• Dietary Fat Metabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Dietary fat positive control	Dietary fat-containing meal plan with a specific supplement that may modify fat metabolism
DIETARY_SUPPLEMENT	Dietary fat negative control	Dietary fat-containing meal plan with a specific supplement that should not modify fat metabolism

Timeline

• Start date: 2024-04-01
• Primary completion: 2025-05-31
• Completion: 2025-05-31
• First posted: 2024-03-15
• Last updated: 2024-12-06

Locations

1 site across 1 country: United States