NCT06313255

A Retrospective Observational Study on the Effects of Probiotics on HBsAg Clearance

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this retrospective observational study is to find out the effects of probiotics on HBV clearance. The main question it aims to answer is: Are the probiotics have an effect in promoting HBV clearance? The participants will observe the HBV clearance rate in chronic hepatitis B patients receive probiotics in addition to the routine antiviral therapy. Researchers will compare the HBV clearance rate in chronic hepatitis B patients receive probiotics and antiviral therapy with those receiving solely antiviral therapy.

Conditions

• Chronic Hepatitis B

Interventions

Type	Name	Description
DRUG	PegIFNα2b	The patients receive PegIFNα2b therapy
DRUG	PegIFNα2b+probiotics	The patients receive both PegIFNα2b and probiotics therapy
DRUG	Nucleoside analog	The patients receive nucleoside analog therapy
DRUG	Nucleoside analog+probiotics	The patients receive both nucleoside analog and probiotics therapy

Timeline

• Start date: 2023-05-09
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-03-15
• Last updated: 2024-05-01

Locations

1 site across 1 country: China