NCT06312618

Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation

Efficacy of Propofol Versus Dexmedetomidine To Prevent Emergence Agitation After Sevoflurane Anesthesia In Children Undergoing Squint Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 3 Years – 7 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: • Which drug is more effective in preventing the appearance of Emergence Agitation in children after sevoflurane anesthesia in squint surgery, propofol or dexmedetomidine? Emergence agitation (EA) is a period of restlessness, agitation, inconsolable crying, disorientation, delusions, and hallucinations with impaired cognition and memory that commonly occurs in children undergoing ophthalmic surgery especially after Short acting volatile agents such as sevoflurane.

Conditions

• Emergence Agitation

Interventions

Type	Name	Description
DRUG	Propofol	After completion of the procedure and after regain muscle power sevoflurane administration will be ceased. children will be randomized to receive propofol 1mg/kg over 10 minutes (group 1) .
DRUG	Dexmedetomidine	After completion of the procedure and after regain muscle power sevoflurane administration will be ceased. children will be randomized to receive dexmedetomidine 0.2 mcg/kg over 10 minutes (group 2).

Timeline

• Start date: 2024-03-15
• Primary completion: 2025-03-15
• Completion: 2025-03-15
• First posted: 2024-03-15
• Last updated: 2025-10-02

Locations

1 site across 1 country: Egypt