NCT06312436

The AT-REBOA Target Trial

The Effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Trauma Patients With Uncontrolled Haemorrhage: Study Protocol for a Target Trial and Its Emulation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 44 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) potentially provides a relatively quick means of achieving this temporary control. In the past years, studies have tried to evaluate the benefit for this method with conflicting results. The previous UK-REBOA trial has not found any benefit in the intervention group and has even hinted at possible harm caused by the intervention. A major limitation of this study is the low number of interventions performed in participating trauma centres and the associated potentially insufficient experience with REBOA. The aim of this study is to evaluate the effectiveness of REBOA in a setting with already experienced providers.

Conditions

• Hemorrhage
• Shock, Traumatic
• Cardiac Arrest Due to Trauma
• Polytrauma

Interventions

Type	Name	Description
PROCEDURE	Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)	Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival.

Timeline

• Start date: 2019-01-01
• Primary completion: 2023-10-01
• Completion: 2024-12-20
• First posted: 2024-03-15
• Last updated: 2025-01-22

Locations

2 sites across 1 country: Austria