NCT06312150

Role of Tumoral Biomarker B3 Adrenergic Receptor in Paediatric Solid Tumours

Retro-prospective Observational Study on the Role of the β3 Adrenergic Receptor as a Tumour Biomarker in Paediatric Solid Tumours

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Meyer Children's Hospital IRCCS · Academic / Other
• Sex: All
• Age: 1 Day – 75 Years
• Healthy volunteers: Accepted

Summary

Childhood cancers are the third leading cause of death among children between the ages of 1 and 4, and the second leading cause of death among children aged 5-14 years. Biologically, it has been demonstrated that tumour aggressiveness and invasive capacity are caused by genetic modifications and cellular microenvironmental factors in a sequential and multifactorial process. The search for genetic alterations, proteins, or entire intracellular signalling pathways involved in the process of carcinogenesis and metastatisation is always evolving in order to identify new prognostic factors or potential therapeutic targets. In recent years, β-adrenergic receptors (β-ARs) have been associated with tumour progression. This is a multicentre biological samples study which main aim is to evaluate the β3 receptor expression in the peripheral blood of patients with solid tumours compared to a healthy control group. The biological samples collected during the study are: peripheral blood sample, bone marrow aspirate and fresh or fresh paraffin biopsy tumour.

Conditions

• Tumor

Interventions

Type	Name	Description
OTHER	Analysis of peripheral blood (control group)	Peripheral blood sample will be acquired in excess to the last scheduled control sample according to clinical practice.
OTHER	Analysis of biological sample (Substudy-solid neoplasms)	peripheral blood sample, bone marrow aspirate and fresh or paraffin biopsia tissutale will be collected for the substudy
OTHER	Analysis of biological sample (substudy-leukaemia patients)	sample of peripheral blood and bone marrow blood for the substudy, derived from paediatric or young adult leukaemia patients

Timeline

• Start date: 2019-12-17
• Primary completion: 2025-09-01
• Completion: 2025-12-01
• First posted: 2024-03-15
• Last updated: 2024-03-18

Locations

3 sites across 1 country: Italy