Trials / Completed
CompletedNCT06307717
Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 8,000 (actual)
- Sponsor
- Chinese PLA General Hospital · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.
Detailed description
Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery. This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | volatile anaesthetic (sevoflurane, isoflurane, desflurane) | Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. |
Timeline
- Start date
- 2020-04-01
- Primary completion
- 2021-10-31
- Completion
- 2022-04-30
- First posted
- 2024-03-13
- Last updated
- 2024-04-10
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06307717. Inclusion in this directory is not an endorsement.