NCT06306625

REmote COnditioning in Out-of-Hospital Cardiac Arrest

REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 220 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury. The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.

Conditions

• Out-Of-Hospital Cardiac Arrest

Interventions

Type	Name	Description
DEVICE	Remote ischemic conditioning	A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of four cycles of a 5-min brachial cuff inflation at 200 mmHg followed by a 5-min of cuff deflation, and is started as soon as possible after randomization. The intervention is repeated 12 and 24 hours after inclusion.
DEVICE	No remote ischemic conditioning	A brachial cuff is positioned around the arm of the patient and no inflation or deflation is performed.

Timeline

• Start date: 2024-06-21
• Primary completion: 2026-06-24
• Completion: 2026-10-05
• First posted: 2024-03-12
• Last updated: 2025-02-12

Locations

14 sites across 1 country: France