NCT06304129

Diagnostic Performance of Plasma Biomarkers of Alzheimer's Disease Compared With CSF Markers

Threshold Values and Diagnostic Performance of Plasma Biomarkers of Alzheimer's Disease Compared With CSF Markers

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 189 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

.The goal of this interventional study is to estimate the diagnostic performance of plasma biomarkers of interest (Aβ40 and Aβ42, P-Tau and NFL), enabling discrimination between patients with and without a pathophysiological AD process. The main questions it aims to answer are: * to define a threshold value for each of the plasma, * to describe the correlations between the plasma biomarkers of interest and the other biological analyses performed as part of care, in particular triglyceridemia, cholesterolemia, glycemia and proteinemia, * to describe biomarker results in relation to comorbidities, in particular dyslipidemia and diabetes * to describe the final diagnosis and results obtained for plasma biomarkers, for patients with intermediate results according to the A/T/N classification (A-/T+ or A+/T-) Participants will be selected among patients undergoing lumbar puncture for the differential diagnosis of AD at Nancy University Hospital.

Conditions

• Alzheimer Blood Biomarkers

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood ponction	Blood ponction

Timeline

• Start date: 2024-04-02
• Primary completion: 2026-01-02
• Completion: 2026-09-02
• First posted: 2024-03-12
• Last updated: 2024-03-12

Locations

1 site across 1 country: France