NCT06302660

Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are: * Study the changes in gut bacteria by examining saliva, stool and blood. * Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria. * Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors. Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires. Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.

Conditions

• Oesophageal Cancer
• Quality of Life
• Bacterial Overgrowth

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Breath test	Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.
DIAGNOSTIC_TEST	Saliva sample	Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.
DIAGNOSTIC_TEST	Blood sample	Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.
DIAGNOSTIC_TEST	Urine sample	Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.
DIAGNOSTIC_TEST	Stool sample	Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.
DIAGNOSTIC_TEST	Health-related Quality of life questionnaires	Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.

Timeline

• Start date: 2022-03-09
• Primary completion: 2025-10-01
• Completion: 2025-12-01
• First posted: 2024-03-12
• Last updated: 2025-01-27

Locations

3 sites across 1 country: United Kingdom