NCT06301802

Outcomes of Proactive Management of Children With Myelomeningocele

Urological Outcomes of Proactive Management of Children With Myelomeningocele

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Spina bifida birth prevalence in Africa is 0.13%. Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Treatment of neuropathic bladder secondary to spina bifida is an ongoing challenge. Damage of the renal parenchyma in children with NB is preventable given adequate evaluation, follow-up and proactive management. Proactive management was defined as use of clean intermittent catheterization (CIC), and/or anticholinergics at presentation, or based on initial high-risk urodynamic findings by 1 year of age. The proactive approach to treat SB (CIC and pharmacotherapy) has contributed to decreasing chronic kidney disease (CKD). Myelomeningocele is considered a complex congenital disease. Hence, a multidisciplinary team is the best choice for management of spina bifida, involving neurosurgeons, orthopedic surgeons, urologists, physical medicine and rehabilitation specialists and pediatricians. Currently, children with spina bifida in Egypt must visit multiple different locations to access the complex care they need. Here, we review our experience with patients with spina bifida who will be followed with this team with an emphasis on patients' upper urinary tract protection and decreasing urinary incontinence.

Conditions

• Urologic Diseases

Interventions

Type	Name	Description
PROCEDURE	CIC	clean intermittent catheterization
DRUG	Anticholinergic	antimuscarinic once daily

Timeline

• Start date: 2024-03-04
• Primary completion: 2026-03-10
• Completion: 2026-03-15
• First posted: 2024-03-08
• Last updated: 2024-03-08

Locations

1 site across 1 country: Egypt