NCT06300021

Bioavailability of Curcuminoids From Turmipure Gold® in Different Food Matrices

A Randomized, Cross-over Clinical Trial to Study the Bioavailability of Curcuminoids From Turmipure Gold® in Different Food Matrices

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Givaudan France Naturals · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to learn about the extent to which turmeric compounds in different food matrices becomes available to the body in healthy volunteers. The main question it aims to answer is: * Is the availability to the body of a turmeric dietary supplement altered when consumed in fruit nectar, oat milk, yogurt drink, or gummies in comparison to a dietary supplement capsule? Participants will ingest a turmeric dietary supplement as a capsule or in different food matrices on six testing days (separated by at least one week). The day before testing day, a standardized dinner will be provided to the participants in the evening and participants will be instructed to not consume any foods or beverages (except water) and to arrive fasted (12 hours) at the investigation site. Participants will ingest turmeric dietary supplement formulations one by one in random order in the morning of testing days. Regular blood and urine samples will be collected before and up to 24 hours after the turmeric dietary supplement ingestion. Standardized meals will be provided during the entire testing day (lunch, mid-afternoon snack, dinner).

Detailed description

Curcumin has been studied as the main bioactive component of the rhizome of the herb Curcuma longa, known as turmeric, and is associated to potential health effects and benefits. Other bioactive components have also been identified, called the curcuminoid group. Curcuminoids are natural yellow-orange pigments and hydrophobic polyphenols derived from. Extracts of turmeric generally contain 75-80% curcumin, 15-20% demethoxycurcumin (DMC), and 0-10% bisdemethoxycurcumin (BDMC). Curcumin and curcuminoids have been extensively investigated due to their antioxidant and anti-inflammatory properties, notably regarding their potential efficacy in modulating various health conditions. In the present trial, the aim is to assess the bioavailability of curcuminoids in different food matrix formulations, the capsule format being the reference matrix, with a hypothesis of equivalence. The primary objective of the study is to assess the plasmatic concentration profile of total curcuminoids (curcumin, DMC, BDMC and their metabolites) on a 24-hour period after consumption of five different food matrix formulations containing TPG in comparison to the dietary supplement capsule formulation.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	TPG capsule	A dietary supplement product in capsule form containing 300 mg Turmipure Gold®
DIETARY_SUPPLEMENT	TPG ready to drink	Ingredient stick containing 300 mg Turmipure Gold® mixed in 60 mL mango fruit nectar
DIETARY_SUPPLEMENT	TPG dairy analog	Ingredient stick containing 300 mg Turmipure Gold® mixed in 240 mL oat milk
DIETARY_SUPPLEMENT	TPG probiotic drink	Ingredient stick containing 300 mg Turmipure Gold® mixed in a 100 mL probiotic yogurt drink base
DIETARY_SUPPLEMENT	TPG gummies	Pectin gummies containing 300 mg Turmipure Gold®
DIETARY_SUPPLEMENT	TPG sport bar	Sport nutrition bar containing 300 mg Turmipure Gold®

Timeline

• Start date: 2021-09-14
• Primary completion: 2022-05-20
• Completion: 2022-05-20
• First posted: 2024-03-08
• Last updated: 2024-03-08

Locations

1 site across 1 country: France