NCT06299618

Environmental Influence on Mental Illness Via Modifications of Genomes and Metabolomes in Adolescents With Autism

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: University College Cork · Academic / Other
• Sex: All
• Age: 11 Years – 15 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to enrich the understanding of the physiological mechanisms that predispose autistic adolescents to mental illness. It will inform a possible pathway and biomarker handprint of mental illness severity and prognosis to formulate a neurobiologically informed personalization strategy that could be applied for selecting appropriate Evidence Based Intervention (EBI) for treating an adolescent formally diagnosed with Autism.

Detailed description

The goal of this observational study is: 1. to identify environmental factors which may significantly contribute to the already vulnerable mental health of autistic adolescents in the age group of 11 - 15 years in developing mental illness; 2. to perform quantitative modelling of the Epigenetic - Genetic/Metabolomic - Mental health (EGM) process chain for designing control strategies based on the subjects' personal, environmental, historical, and current state.

Conditions

• Autism
• Autism Spectrum Disorder

Timeline

• Start date: 2024-09-01
• Primary completion: 2025-05-01
• Completion: 2025-12-01
• First posted: 2024-03-08
• Last updated: 2024-08-14

Locations

3 sites across 3 countries: Ireland, Romania, United Kingdom