Trials / Recruiting
RecruitingNCT06298682
Characterization of Exosomes Platelets-released
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 175 (estimated)
- Sponsor
- Centro Cardiologico Monzino · Academic / Other
- Sex
- All
- Age
- 20 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics. EVs include three classes: small EVs (exosomes), large EVs (microparticles), and apoptotic bodies. Platelet-derived EVs (PEVs) are the most abundant class in human blood and can actively participate in numerous physiological and pathological processes. The information about the role of platelet exosomes in cardiovascular disease and the effect of antiplatelet agents on their release and content is very limited.
Detailed description
This study is a multicentre, observational. We plan to enrol 54 subjects from Centro Cardiologico Monzino IRCCS, and 121 buffy coat related to 121 subjects from Centro Trasfusionale Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. biographical and anthropomorphic data will be recorded, a fasting blood venous sample (from ante-cubital vein) will be collected for the haematochemical analyses and for research samples.
Conditions
Timeline
- Start date
- 2021-07-08
- Primary completion
- 2026-07-07
- Completion
- 2027-07-07
- First posted
- 2024-03-07
- Last updated
- 2024-03-12
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06298682. Inclusion in this directory is not an endorsement.