NCT06298318

Metabolic Changes in Healthy Subjects with Acute Binge Drink

Effect of Acute Binge Drink Intervention on Healthy Young Subjects: a Double-blinded, Randomized Trial

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Zhejiang Chinese Medical University · Other Government
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drinking on liver function, liver fat content, and lipid metabolism in healthy young subjects. The main questions it aims to answer are: 1\. If acute binge drinking could alleviate liver injury and hepatic steatosis.

Detailed description

The goal of this double-blinded, randomized trial is to investigate the effects of acute binge drinking on liver function, liver fat content, and lipid metabolism in healthy young subjects. The main questions it aims to answer are: 1\. If acute binge drinking could alleviate liver injury and hepatic steatosis. Participants will be randomized into two groups (n=40) and provided vodka (1 g/kg body weight) or an equal amount of non-alcoholic beverages with the same taste and colour but without alcohol, respectively. 15 minutes later, they are successively provided with the same breakfast. Venous blood samples were collected at 0h, 1h, 3h, 5h, 6h, 12h, and 24h from each subject, respectively.

Conditions

• Binge Drinking
• Liver Injury
• Hepatic Steatosis

Interventions

Type	Name	Description
OTHER	Vodka	BMI: if 18.5 ≤ BMI \< 24.0, individuals received 1.0 g/kg body weight of vodka; if 24.0 ≤ BMI ≤ 28.0, individuals received 0.8 g/kg body weight of vodka.
OTHER	water	equal amount of non-alcoholic beverages with the same taste and colour but without alcohol

Timeline

• Start date: 2024-04-27
• Primary completion: 2024-09-19
• Completion: 2024-11-18
• First posted: 2024-03-07
• Last updated: 2025-01-22

Locations

1 site across 1 country: China