NCT06296875

The Krill Ageing Muscle Mechanisms (KAMM) Study

Uncovering the Mechanisms Through Which Krill Oil Increases Muscle Function in Older Adults.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: University of Glasgow · Academic / Other
• Sex: All
• Age: 65 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length). Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy. Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.

Conditions

• Sarcopenia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vegetable oil	mixed vegetable oil
DIETARY_SUPPLEMENT	Krill oil	Krill oil

Timeline

• Start date: 2024-09-01
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2024-03-06
• Last updated: 2025-03-30

Locations

1 site across 1 country: United Kingdom